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A small-molecule fusion inhibitor of influenza virus is orally active in mice.
van Dongen, Maria J P; Kadam, Rameshwar U; Juraszek, Jarek; Lawson, Edward; Brandenburg, Boerries; Schmitz, Frederike; Schepens, Wim B G; Stoops, Bart; van Diepen, Harry A; Jongeneelen, Mandy; Tang, Chan; Vermond, Jan; van Eijgen-Obregoso Real, Alida; Blokland, Sven; Garg, Divita; Yu, Wenli; Goutier, Wouter; Lanckacker, Ellen; Klap, Jaco M; Peeters, Daniëlle C G; Wu, Jin; Buyck, Christophe; Jonckers, Tim H M; Roymans, Dirk; Roevens, Peter; Vogels, Ronald; Koudstaal, Wouter; Friesen, Robert H E; Raboisson, Pierre; Dhanak, Dashyant; Goudsmit, Jaap; Wilson, Ian A.
Afiliação
  • van Dongen MJP; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands. mvandon@its.jnj.com wilson@scripps.edu.
  • Kadam RU; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.
  • Juraszek J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
  • Lawson E; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Brandenburg B; Discovery Sciences, Janssen Research & Development, 1400 McKean Rd., Spring House, PA, USA.
  • Schmitz F; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Schepens WBG; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands.
  • Stoops B; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • van Diepen HA; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.
  • Jongeneelen M; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.
  • Tang C; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Vermond J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • van Eijgen-Obregoso Real A; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands.
  • Blokland S; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Garg D; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands.
  • Yu W; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Goutier W; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Lanckacker E; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Klap JM; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands.
  • Peeters DCG; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Wu J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
  • Buyck C; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Jonckers THM; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium.
  • Roymans D; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Roevens P; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.
  • Vogels R; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium.
  • Koudstaal W; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.
  • Friesen RHE; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium.
  • Raboisson P; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium.
  • Dhanak D; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.
  • Goudsmit J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.
  • Wilson IA; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands.
Science ; 363(6431)2019 03 08.
Article em En | MEDLINE | ID: mdl-30846569
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Tetrazóis / Materiais Biomiméticos / Influenza Humana / Vírus da Influenza A Subtipo H1N1 / Internalização do Vírus / Anticorpos Neutralizantes / Inibidores de Proteínas Virais de Fusão Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Piridinas / Tetrazóis / Materiais Biomiméticos / Influenza Humana / Vírus da Influenza A Subtipo H1N1 / Internalização do Vírus / Anticorpos Neutralizantes / Inibidores de Proteínas Virais de Fusão Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos