Sacubitril/Valsartan and Mexiletine: A Proarrhythmic Combination?
Cardiology
; 142(1): 4-6, 2019.
Article
em En
| MEDLINE
| ID: mdl-30852576
ABSTRACT
The uptake of sacubitril/valsartan since the PARADIGM study confirmed its beneficial effects on outcomes over enalapril in chronic systolic heart failure has inevitably led to potential interactions with co-prescribed medications in real-world patients. We report two cases that raise the possibility of an interaction between sacubitril/valsartan and the class Ib anti-arrhythmic mexiletine resulting in proarrhythmic effects. We discuss the pharmacokinetics of both agents and posit potential mechanistic interactions that suggest caution should be used and careful monitoring for (ventricular) arrhythmias applied in patients receiving sacubitril/valsartan and mexiletine.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
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Tetrazóis
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Antagonistas de Receptores de Angiotensina
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Aminobutiratos
/
Mexiletina
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Cardiology
Ano de publicação:
2019
Tipo de documento:
Article