Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription.

Katona, Bryson W; Glynn, Rebecca A; Paulosky, Kayla E; Feng, Zijie; Davis, Caroline I; Ma, Jian; Berry, Corbett T; Szigety, Katherine M; Matkar, Smita; Liu, Yuanyuan; Wang, Haoren; Wu, Yuan; He, Xin; Freedman, Bruce D; Brady, Donita C; Hua, Xianxin

Katona, Bryson W; Glynn, Rebecca A; Paulosky, Kayla E; Feng, Zijie; Davis, Caroline I; Ma, Jian; Berry, Corbett T; Szigety, Katherine M; Matkar, Smita; Liu, Yuanyuan; Wang, Haoren; Wu, Yuan; He, Xin; Freedman, Bruce D; Brady, Donita C; Hua, Xianxin.

Afiliação

Katona BW; Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Glynn RA; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Paulosky KE; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Feng Z; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Davis CI; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Ma J; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Berry CT; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Szigety KM; Department of Pathobiology and Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania.
Matkar S; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania.
Liu Y; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Wang H; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Wu Y; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
He X; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Freedman BD; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Brady DC; Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, China.
Hua X; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Cancer Res ; 79(9): 2195-2207, 2019 05 01.

Article em En | MEDLINE | ID: mdl-30877106

Assuntos

Cálcio/metabolismo; Neoplasias Colorretais/tratamento farmacológico; Sinergismo Farmacológico; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Proteínas Proto-Oncogênicas/antagonistas & inibidores; Proteínas Quinases Associadas a Fase S/antagonistas & inibidores; Animais; Apoptose; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Proliferação de Células; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Quimioterapia Combinada; Inibidores Enzimáticos/farmacologia; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/genética; Receptores ErbB/metabolismo; Feminino; Gefitinibe/farmacologia; Humanos; Receptores de Inositol 1,4,5-Trifosfato/genética; Receptores de Inositol 1,4,5-Trifosfato/metabolismo; Camundongos; Camundongos Nus; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas/genética; Proteínas Proto-Oncogênicas/metabolismo; Proteínas Quinases Associadas a Fase S/genética; Proteínas Quinases Associadas a Fase S/metabolismo; Tapsigargina/farmacologia; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Regulação Neoplásica da Expressão Gênica / Cálcio / Proteínas Proto-Oncogênicas / Proteínas Quinases Associadas a Fase S / Sinergismo Farmacológico Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos

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