Arsenic exposure of child populations in Northern Argentina.
Sci Total Environ
; 669: 1-6, 2019 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-30877956
ABSTRACT
Chronic exposure to inorganic arsenic (As) is associated with numerous adverse effects. Argentina is one of the countries affected by arsenicism; however, there are few studies that evaluate inorganic As exposure and its effects on child population. The aim of this study is to evaluate exposure to As through water and food in child populations living in the provinces of Santiago del Estero and Chaco (nâ¯=â¯101), and to determine the impact of this exposure analysing biomarkers of exposure (urine and hair As contents) and effect [8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG)]. The populations selected live in three areas with different levels of As in the drinking water (Santa Teresa de Carballo, 0.925â¯mg/L; Taco Pozo, 0.210â¯mg/L; Jumi Pozo, 0.016â¯mg/L). The As intakes through water and food are especially high in the areas with the greatest As exposure (Santa Teresa de Carballo, 1575⯱â¯8⯵g/day; Taco Pozo, 386⯱â¯8⯵g/day; Jumi Pozo, 39⯱â¯1⯵g/day). The total As contents in most of the samples of hair (0.11-13.11â¯mg/kg) and urine (31-4258⯵g/g creatinine) are higher than the reference values (hair 1â¯mg/kg; urine 50⯵g/g creatinine). The increase in the level of As exposure alters the profile of metabolites in urine, with a decrease of dimethylarsinic acid (10%) and an increase in the percentages of monomethylarsonic acid (4%) and inorganic As (6%). The results also show high values of 8-OHdG (3.7-37.8⯵g/g creatinine), a oxidative DNA damage marker, in the two areas with greater As exposure.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arsênio
/
Arsenicais
/
Desoxiguanosina
/
Exposição Ambiental
/
Poluentes Ambientais
/
Cabelo
Limite:
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Sci Total Environ
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Espanha