The results of aflibercept therapy as a first line treatment of age-related macular degeneration.
J Curr Ophthalmol
; 31(1): 66-71, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30899849
ABSTRACT
PURPOSE:
To report the results of aflibercept treatment in treatment-naive neovascular age-related macular degeneration (AMD) patients and suggest a suitable treatment algorithm for routine clinical practice.METHOD:
The medical charts of patients treated with intravitreal aflibercept for neovascular AMD were reviewed retrospectively. Best corrected visual acuity, slit-lamp examination, dilated fundus examination, applanation tonometry, and a total number of aflibercept injections were recorded. Aflibercept therapy was applied in an as-needed algorithm after three monthly loading dose. Additionally, optic coherence tomography data, including presence or absence of macular fluid and central macular thickness were recorded.RESULTS:
Thirty-eight eyes of 36 patients were included in this study. The mean number of aflibercept injections was 4.86 ± 2.76 (3-18). Mean follow-up time was 12.1 ± 5.7 months (6-26). Thirty-seven eyes (97.3%) achieved maintenance of vision. The mean best corrected visual acuity (logMAR) increased from 0.98 ± 0.56 (0.2-2.4) to 0.57 ± 0.31 (0.1-1.3), (P = 0.001). Mean visual acuity gain was 15.86 ± 12.18 letters at the end of the study. The mean central macular thickness decreased from 327.9 ± 56.5 µm (219-474 µm) to 277.0 ± 53.0 µm (197-405 µm), (P = 0.016).CONCLUSIONS:
Aflibercept therapy appears to be a safe and effective treatment for neovascular AMD. Injections applied in an as-needed algorithm after three monthly loading doses were successful to maintain and improve visual acuity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Curr Ophthalmol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Turquia