The Effect of Branched Chain Amino Acids-Enriched Nutritional Supplements on Activities of Daily Living and Muscle Mass in Inpatients with Gait Impairments: A Randomized Controlled Trial.
J Nutr Health Aging
; 23(4): 348-353, 2019.
Article
em En
| MEDLINE
| ID: mdl-30932133
ABSTRACT
OBJECTIVE:
To investigate the effects of continuous intervention with branched chain amino acids-enriched nutritional supplements from the acute phase to convalescent rehabilitation wards in inpatients with gait impairments.DESIGN:
Open-label, randomized, parallel-group comparison study (UMIN Clinical Trials Registry ID UMIN000018640).SETTING:
Acute care and convalescent rehabilitation wards.PARTICIPANTS:
We studied 80 patients undergoing stand/gait training.INTERVENTIONS:
Participants in the intervention group (RJ group) received nutritional supplements (jelly foods comprising 2500 mg BCAA and 20 IU vitamin D) twice a day until hospital discharge. MEASUREMENTS The primary outcome was the motor components of the Functional Independence Measure (FIM-m), and the secondary outcome was skeletal muscle mass index.RESULTS:
Analyses were conducted on 55 patients who were able to perform stand/gait training continuously from the acute until the recovery phases. FIM-m was significantly elevated in the RJ group and the control group , but no difference was noted between the two groups. Only the RJ group showed a significant increase in skeletal muscle mass index, and the amount of variation was significantly different between the two groups (the control group decreased an average of 2.2% and the RJ group increased an average of 4.3%; P = 0.014). A significant decrease in body weight was found only in the control group (P = 0.084).CONCLUSIONS:
Nutritional interventions using branched chain amino acids (BCAA)-enriched nutritional supplements demonstrated no significant difference in activities of daily living; however, an increase in skeletal muscle mass was noted. Skeletal muscle mass and body weight differed significantly between the two groups, and BCAA-enriched nutritional supplements intake in acute and convalescent rehabilitation wards may be effective for the prevention of malnutrition and sarcopenia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Suplementos Nutricionais
/
Limitação da Mobilidade
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Sarcopenia
/
Marcha
/
Aminoácidos de Cadeia Ramificada
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
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Humans
/
Male
Idioma:
En
Revista:
J Nutr Health Aging
Assunto da revista:
CIENCIAS DA NUTRICAO
/
GERIATRIA
Ano de publicação:
2019
Tipo de documento:
Article