Development of an on-line analytical platform to screen haptens in shuxuening injection based on high-performance liquid chromatography coupled with ion-trap multistage mass spectrometry and human serum albumin fluorescence detection.

Niu, Yanyan; Wang, Hong; Tong, Xin; Li, Xiang; Guo, Ning; Zhang, Xiaotian; Luo, Yukun; Gao, Yaning; He, Tian; Lin, Zongtao; Chen, Shizhong

Niu, Yanyan; Wang, Hong; Tong, Xin; Li, Xiang; Guo, Ning; Zhang, Xiaotian; Luo, Yukun; Gao, Yaning; He, Tian; Lin, Zongtao; Chen, Shizhong.

Afiliação

Niu Y; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Wang H; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Tong X; College of Life Science, Capital Normal University, Beijing, 100048, China.
Li X; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Guo N; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zhang X; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Luo Y; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Gao Y; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
He T; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Lin Z; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, United States. Electronic address: zongtao@sas.upenn.edu.
Chen S; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address: chenshizhong66@163.com.

J Chromatogr A ; 1598: 232-241, 2019 Aug 02.

Article em En | MEDLINE | ID: mdl-30981514

Assuntos

Química Farmacêutica/métodos; Cromatografia Líquida de Alta Pressão; Medicamentos de Ervas Chinesas/química; Haptenos/análise; Espectrometria de Massas; Albumina Sérica Humana/análise; Química Farmacêutica/instrumentação; Fluorescência; Humanos; Reprodutibilidade dos Testes

Palavras-chave

Hapten; Human serum albumin; On-line method; RBL-2H3 cell; Shuxuening injection

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Medicamentos de Ervas Chinesas / Química Farmacêutica / Cromatografia Líquida de Alta Pressão / Albumina Sérica Humana / Haptenos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: J Chromatogr A Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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