VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence.
Pharmacogenomics
; 20(5): 331-341, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30983500
ABSTRACT
Aim:
To determine if selected serotonergic and noradrenergic gene variants are associated with heroin addiction. Subjects &methods:
A total of 126 variants in 19 genes in subjects with Dutch European ancestry from The Netherlands. Subjects included 281 opioid-dependent volunteers in methadone maintenance or heroin-assisted treatment, 163 opioid-exposed but not opioid-dependent volunteers who have been using illicit opioids but never became opioid-dependent and 153 healthy controls.Results:
Nominal associations were indicated for 20 variants in six genes including an experiment-wise significant association from the combined effect of three SLC18A2 SNPs (rs363332, rs363334 and rs363338) with heroin dependence (pfinal = 0.047).Conclusion:
Further studies are warranted to confirm and elucidate the role of these variants in the vulnerability to opioid addiction.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Nucleotídeo Único
/
Proteínas Vesiculares de Transporte de Monoamina
/
Transtornos Relacionados ao Uso de Opioides
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Pharmacogenomics
Assunto da revista:
FARMACOLOGIA
/
GENETICA MEDICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos