Inhibitory effects of homoharringtonine on foot and mouth disease virus in vitro.
J Med Virol
; 91(9): 1595-1601, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31032977
ABSTRACT
Foot-and-mouth disease (FMD) is a highly contagious disease that affects cloven-hoof animals including cattle, swine, sheep, goats, and lots of wild species. Effectively control measures are urged needed. Here, we showed that homoharringtonine treatment exhibited a strong inhibitory effect against two different strains of FMDVs (O/MYA98/BY/2010 and A/GD/MM/2013) in swine kidney (IBRS-2) cells. Further experiments demonstrated that homoharringtonine did not affect virus attachment or entry. Using time-of-addition assays, we found that the antiviral activity of homoharringtonine occurred primarily during the early stage of infection. These results demonstrated that homoharringtonine might be an effective anti-FMDV drug. Further studies are required to explore the antiviral activity of homoharringtonine against FMDV replication in vivo.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Vírus da Febre Aftosa
/
Febre Aftosa
/
Mepesuccinato de Omacetaxina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China