Dodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency.
Nanomedicine (Lond)
; 14(12): 1579-1593, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-31038003
ABSTRACT
Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations of CrT. Aim:
This work focus on the preclinical development of a new therapeutic approach based on a microemulsion (ME) as drug delivery system for dodecyl creatine ester (DCE). Materials &methods:
DCE-ME was prepared by titration method. Novel object recognition (NOR) tests were performed before and after DCE-ME treatment on Slc6a8-/y mice.Results:
Intranasal administration with DCE-ME improved NOR performance in Slc6a8-/y mice. Slc6a8-/y mice treated with DCE-ME had increased striatal ATP levels mainly in the striatum compared with vehicle-treated Slc6a8-/y mice which was associated with increased expression of synaptic markers.Conclusion:
These results highlight the potential value of DCE-ME as promising therapy for creatine transporter deficiency.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Creatina
/
Encefalopatias Metabólicas Congênitas
/
Deficiência Intelectual Ligada ao Cromossomo X
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Emulsões
/
Proteínas da Membrana Plasmática de Transporte de Neurotransmissores
Limite:
Animals
Idioma:
En
Revista:
Nanomedicine (Lond)
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
França