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Encapsulation of Silver Nanoparticles in Polylactic Acid or Poly(lactic-co-glycolic acid) and Their Antimicrobial and Cytotoxic Activities.
Guerrero, Daissy Julieth Paredes; Bonilla, Jhon Jhamilton Artunduaga; López, Claudia Cristina Ortiz; Sáez, Rodrigo Gonzalo Torres.
Afiliação
  • Guerrero DJP; Grupo de Investigación en Bioquímica y Microbiología (GIBIM), Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, (680002) Bucaramanga, Colombia.
  • Bonilla JJA; Laboratorio de Glicobiologia de Eucariotos (LaGE), Instituto de Microbiologia Paulo de Góes, Departamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro (21941-901), Rio de Janeiro, Brasil.
  • López CCO; Grupo de Investigación en Bioquímica y Microbiología, (GIBIM), Escuela de Microbiología, Facultad de Salud, Universidad Industrial de Santander, (680002) Bucaramanga, Colombia.
  • Sáez RGT; Grupo de Investigación en Bioquímica y Microbiología (GIBIM), Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, (680002) Bucaramanga, Colombia.
J Nanosci Nanotechnol ; 19(11): 6933-6941, 2019 11 01.
Article em En | MEDLINE | ID: mdl-31039844
Encapsulation with biodegradable polymers is an alternative to reduce adverse effects and improve the physicochemical properties of metallic nanoparticles. In this study, spherical polymeric nanoparticles with an average size of 200 nm loaded with silver nanoparticles (AgNPs) were obtained. The antimicrobial activity against Escherichia coli O157:H7, methicillin-resistant Staphylococcus aureus (MRSA), and yeasts as Candida albicans, Candida parapsilosis and Candida guilliermondii was determined. MIC90 values of nanocomposites were between 0.01 to 1 µg/mL, potentialized effect up to 500 times compared to free AgNPs. In addition, cytotoxic effect on 50% of murine fibroblast (CC50) was obtained at a mean concentration of 9.57 µg/mL of AgNPs (up to ~1000 times higher than MIC90). Consequently, the polymeric nanocomposites loaded with AgNPs are a potential alternative in the development of new biocide agents on Candida species and pathogenic bacteria at non-toxic concentrations for mammalian cells such as murine fibroblasts.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas Metálicas / Staphylococcus aureus Resistente à Meticilina / Anti-Infecciosos Limite: Animals Idioma: En Revista: J Nanosci Nanotechnol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas Metálicas / Staphylococcus aureus Resistente à Meticilina / Anti-Infecciosos Limite: Animals Idioma: En Revista: J Nanosci Nanotechnol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos