Design, synthesis and antitumor evaluation of novel celastrol derivatives.

Xu, Manyi; Li, Na; Zhao, Zihao; Shi, Zhixian; Sun, Jianbo; Chen, Li

Xu, Manyi; Li, Na; Zhao, Zihao; Shi, Zhixian; Sun, Jianbo; Chen, Li.

Afiliação

Xu M; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China.
Li N; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China.
Zhao Z; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China.
Shi Z; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China.
Sun J; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China. Electronic address: sunjianbo@cpu.edu.cn.
Chen L; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China. Electronic address: chenli627@cpu.edu.cn.

Eur J Med Chem ; 174: 265-276, 2019 Jul 15.

Article em En | MEDLINE | ID: mdl-31051401

Assuntos

Antineoplásicos/farmacologia; Triterpenos/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Proteínas de Ciclo Celular/metabolismo; Linhagem Celular Tumoral; Chaperoninas/metabolismo; Desenho de Fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos; Proteínas de Choque Térmico HSP90/metabolismo; Humanos; Estrutura Molecular; Triterpenos Pentacíclicos; Ligação Proteica/efeitos dos fármacos; Relação Estrutura-Atividade; Triterpenos/síntese química; Triterpenos/química

Palavras-chave

Anti-tumor; Apoptosis; Celastrol; Ferulic acid; Hybridization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de publicação: França

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