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Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.
Willis, Cory M; Nicaise, Alexandra M; Menoret, Antoine; Ryu, Jae Kyu; Mendiola, Andrew S; Jellison, Evan R; Givogri, Maria I; Han, David K; Bongarzone, Ernesto R; Akassoglou, Katerina; Vella, Anthony T; Crocker, Stephen J.
Afiliação
  • Willis CM; Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030.
  • Nicaise AM; Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030.
  • Menoret A; Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030.
  • Ryu JK; Institute for Systems Genomics, UConn Health, Farmington, CT 06030.
  • Mendiola AS; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.
  • Jellison ER; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.
  • Givogri MI; Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030.
  • Han DK; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612.
  • Bongarzone ER; Department of Cell Biology, University of Connecticut School of Medicine, Farmington, CT 06030.
  • Akassoglou K; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612.
  • Vella AT; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.
  • Crocker SJ; Department of Neurology, University of California, San Francisco, CA 94143.
Proc Natl Acad Sci U S A ; 116(21): 10488-10493, 2019 05 21.
Article em En | MEDLINE | ID: mdl-31068461
ABSTRACT
Extracellular vesicles (EVs) are emerging as potent mediators of intercellular communication with roles in inflammation and disease. In this study, we examined the role of EVs from blood plasma (pEVs) in an experimental autoimmune encephalomyelitis mouse model of central nervous system demyelination. We determined that pEVs induced a spontaneous relapsing-remitting disease phenotype in MOG35-55-immunized C57BL/6 mice. This modified disease phenotype was found to be driven by CD8+ T cells and required fibrinogen in pEVs. Analysis of pEVs from relapsing-remitting multiple sclerosis patients also identified fibrinogen as a significant portion of pEV cargo. Together, these data suggest that fibrinogen in pEVs contributes to the perpetuation of neuroinflammation and relapses in disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrinogênio / Linfócitos T CD8-Positivos / Encefalomielite Autoimune Experimental / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrinogênio / Linfócitos T CD8-Positivos / Encefalomielite Autoimune Experimental / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article