Novel 4-Acrylamido-Quinoline Derivatives as Potent PI3K/mTOR Dual Inhibitors: The Design, Synthesis, and <i>in vitro</i> and <i>in vivo</i> Biological Evaluation.

Ma, Xiaodong; Shen, Li; Zhang, Jiankang; Liu, Guoqiang; Zhan, Shuyu; Ding, Baoyue; Lv, Xiaoqing

Novel 4-Acrylamido-Quinoline Derivatives as Potent PI3K/mTOR Dual Inhibitors: The Design, Synthesis, and in vitro and in vivo Biological Evaluation.

Ma, Xiaodong; Shen, Li; Zhang, Jiankang; Liu, Guoqiang; Zhan, Shuyu; Ding, Baoyue; Lv, Xiaoqing.

Afiliação

Ma X; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Shen L; Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei, China.
Zhang J; Ocean College, Zhejiang University, Zhoushan, China.
Liu G; Zhejiang University City College, Hangzhou, China.
Zhan S; College of Medicine, Jiaxing University, Jiaxing, China.
Ding B; College of Medicine, Jiaxing University, Jiaxing, China.
Lv X; College of Medicine, Jiaxing University, Jiaxing, China.

Front Chem ; 7: 236, 2019.

Article em En | MEDLINE | ID: mdl-31069214

Palavras-chave

4-acrylamido-quinolines; PI3K/Akt/mTOR signaling; PI3K/mTOR dual inhibitors; PK study; anti-proliferative activity; metabolic stability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Suíça

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