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Misophonia is associated with altered brain activity in the auditory cortex and salience network.
Schröder, Arjan; van Wingen, Guido; Eijsker, Nadine; San Giorgi, Renée; Vulink, Nienke C; Turbyne, Collin; Denys, Damiaan.
Afiliação
  • Schröder A; Amsterdam University Medical Centers, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands. a.e.schroder@amsterdamumc.nl.
  • van Wingen G; Amsterdam Neuroscience, Amsterdam, The Netherlands. a.e.schroder@amsterdamumc.nl.
  • Eijsker N; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands. a.e.schroder@amsterdamumc.nl.
  • San Giorgi R; Amsterdam University Medical Centers, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.
  • Vulink NC; Amsterdam Neuroscience, Amsterdam, The Netherlands.
  • Turbyne C; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands.
  • Denys D; Amsterdam University Medical Centers, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.
Sci Rep ; 9(1): 7542, 2019 05 17.
Article em En | MEDLINE | ID: mdl-31101901
ABSTRACT
Misophonia is characterized by intense rage and disgust provoked by hearing specific human sounds resulting in social isolation due to avoidance. We exposed patients with symptom provoking audiovisual stimuli to investigate brain activity of emotional responses. 21 patients with misophonia and 23 matched healthy controls were recruited at the psychiatry department of the Amsterdam UMC. Participants were presented with three different conditions, misophonia related cues (video clips with e.g. lip smacking and loud breathing), aversive cues (violent or disgusting clips from movies), and neutral cues (video clips of e.g. someone meditating) during fMRI. Electrocardiography was recorded to determine physiological changes and self-report measures were used to assess emotional changes. Misophonic cues elicited anger, disgust and sadness in patients compared to controls. Emotional changes were associated with increases in heart rate. The neuroimaging data revealed increased activation of the right insula, right anterior cingulate cortex and right superior temporal cortex during viewing of the misophonic video clips compared to neutral clips. Our results demonstrate that audiovisual stimuli trigger anger and physiological arousal in patients with misophonia, associated with activation of the auditory cortex and salience network.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fúria / Hiperacusia / Córtex Auditivo / Sintomas Afetivos / Agressão Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fúria / Hiperacusia / Córtex Auditivo / Sintomas Afetivos / Agressão Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda