Knockdown of KIAA1199 suppresses IL-1ß-induced cartilage degradation and inflammatory responses in human chondrocytes through the Wnt/ß-catenin signalling pathway.

Ding, Qian-Hai; Qi, Yi-Ying; Li, Xiu-Mao; Chen, Wei-Ping; Wang, Xiang-Hua; Ji, Xiao-Wei

Ding, Qian-Hai; Qi, Yi-Ying; Li, Xiu-Mao; Chen, Wei-Ping; Wang, Xiang-Hua; Ji, Xiao-Wei.

Afiliação

Ding QH; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Qi YY; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Li XM; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Chen WP; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Wang XH; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China.
Ji XW; Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jie Fang Road 88#, 310009 Hangzhou, People's Republic of China. Electronic address: xwji2013@zju.edu.cn.

Int Immunopharmacol ; 73: 203-211, 2019 Aug.

Article em En | MEDLINE | ID: mdl-31103876

Assuntos

Cartilagem Articular/metabolismo; Condrócitos/metabolismo; Hialuronoglucosaminidase/metabolismo; Interleucina-1beta; Osteoartrite/metabolismo; Via de Sinalização Wnt; Animais; Células Cultivadas; Técnicas de Silenciamento de Genes; Humanos; Hialuronoglucosaminidase/sangue; Hialuronoglucosaminidase/genética; Masculino; Ratos Sprague-Dawley; Regulação para Cima

Palavras-chave

Cartilage degradation; Chondrocytes; Inflammatory responses; KIAA1199; Osteoarthritis; Wnt/ß-catenin signalling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Cartilagem Articular / Condrócitos / Interleucina-1beta / Via de Sinalização Wnt / Hialuronoglucosaminidase Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de publicação: Holanda

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