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Propofol reduces microglia activation and neurotoxicity through inhibition of extracellular vesicle release.
Liu, Jianhui; Li, Yuju; Xia, Xiaohuan; Yang, Xiaoyu; Zhao, Runze; Peer, Justin; Wang, Hongyun; Tong, Zenghan; Gao, Fengtong; Lin, Hai; Wu, Beiqing; Huang, Yunlong; Zheng, Jialin C.
Afiliação
  • Liu J; Department of Anesthesiology, Tongji Hospital affiliated to Tongji University School of Medicine, Shanghai, China; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Li Y; Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital affiliated to Tongji University School of Medicine, Shanghai, China; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Xia X; Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital affiliated to Tongji University School of Medicine, Shanghai, China.
  • Yang X; Department of Anesthesiology, Tongji Hospital affiliated to Tongji University School of Medicine, Shanghai, China.
  • Zhao R; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Peer J; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Wang H; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Tong Z; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Gao F; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Lin H; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Wu B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Huang Y; Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital affiliated to Tongji University School of Medicine, Shanghai, China; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
  • Zheng JC; Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital affiliated to Tongji University School of Medicine, Shanghai, China; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
J Neuroimmunol ; 333: 476962, 2019 08 15.
Article em Fr | MEDLINE | ID: mdl-31108401
ABSTRACT
Propofol is an established anesthetic widely used for induction and maintenance of anesthesia. We investigated propofol for its anti-inflammatory effects on microglia and found that propofol treatment is associated with substantial lower levels of extracellular vesicles (EVs) in immune activated microglia. Importantly, EVs collected from immune activated microglia reversed propofol-mediated anti-inflammatory and neuroprotective effects, suggesting that propofol reduces proinflammatory microglia activation and microglia-mediated neurotoxicity through inhibition of EV release. These data shed new insight into a novel molecular mechanism of propofol-mediated neuroprotective and immunomodulatory effects through inhibition of EV release.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propofol / Microglia / Fármacos Neuroprotetores / Vesículas Extracelulares / Anti-Inflamatórios Limite: Humans Idioma: Fr Revista: J Neuroimmunol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propofol / Microglia / Fármacos Neuroprotetores / Vesículas Extracelulares / Anti-Inflamatórios Limite: Humans Idioma: Fr Revista: J Neuroimmunol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos