Disulfiram inhibits epithelial-mesenchymal transition through TGFß-ERK-Snail pathway independently of Smad4 to decrease oral squamous cell carcinoma metastasis.

Bu, Wenhuan; Wang, Zilin; Meng, Lin; Li, Xing; Liu, Xinchen; Chen, Yumeng; Xin, Ying; Li, Baoquan; Sun, Hongchen

Bu, Wenhuan; Wang, Zilin; Meng, Lin; Li, Xing; Liu, Xinchen; Chen, Yumeng; Xin, Ying; Li, Baoquan; Sun, Hongchen.

Afiliação

Bu W; Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, 130000 Changchun, People's Republic of China.
Wang Z; Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, 130000 Changchun, People's Republic of China.
Meng L; Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, 130000 Changchun, People's Republic of China.
Li X; School and Hospital of Stomatology, China Medical University, 110000 Shenyang, People's Republic of China.
Liu X; Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, 130000 Changchun, People's Republic of China.
Chen Y; Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, 130000 Changchun, People's Republic of China.
Xin Y; Department of Oral Pathology, Hospital of Stomatology, Xi'an Jiaotong University, Xi'an, 710000, People's Republic of China.
Li B; Department of Temporomandibular Joint, School and Hospital of Stomatology, Jilin University, 130000 Changchun, People's Republic of China.
Sun H; Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, 130000 Changchun, People's Republic of China.

Cancer Manag Res ; 11: 3887-3898, 2019.

Article em En | MEDLINE | ID: mdl-31118804

Palavras-chave

Smad4 mutation; disulfiram; epithelialmesenchymal transition; oral squamous cell carcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cancer Manag Res Ano de publicação: 2019 Tipo de documento: Article