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Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature.
Fergusson, Dean A; Avey, Marc T; Barron, Carly C; Bocock, Mathew; Biefer, Kristen E; Boet, Sylvain; Bourque, Stephane L; Conic, Isidora; Chen, Kai; Dong, Yuan Yi; Fox, Grace M; George, Ronald B; Goldenberg, Neil M; Gragasin, Ferrante S; Harsha, Prathiba; Hong, Patrick J; James, Tyler E; Larrigan, Sarah M; MacNeil, Jenna L; Manuel, Courtney A; Maximos, Sarah; Mazer, David; Mittal, Rohan; McGinn, Ryan; Nguyen, Long H; Patel, Abhilasha; Richebé, Philippe; Saha, Tarit K; Steinberg, Benjamin E; Sampson, Sonja D; Stewart, Duncan J; Syed, Summer; Vella, Kimberly; Wesch, Neil L; Lalu, Manoj M.
Afiliação
  • Fergusson DA; Clinical Epidemiology Program, Blueprint Translational Research Group, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Avey MT; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Barron CC; Clinical Epidemiology Program, Blueprint Translational Research Group, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Bocock M; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Biefer KE; Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.
  • Boet S; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Bourque SL; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Conic I; Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada.
  • Chen K; Clinical Epidemiology Program, Blueprint Translational Research Group, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Dong YY; Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
  • Fox GM; Department of Innovation in Medical Education, University of Ottawa, Ottawa, Ontario, Canada.
  • George RB; Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada.
  • Goldenberg NM; Clinical Epidemiology Program, Blueprint Translational Research Group, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Gragasin FS; Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada.
  • Harsha P; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Hong PJ; Clinical Epidemiology Program, Blueprint Translational Research Group, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • James TE; Department of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Larrigan SM; Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada.
  • MacNeil JL; Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada.
  • Manuel CA; Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.
  • Maximos S; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Mazer D; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Mittal R; Clinical Epidemiology Program, Blueprint Translational Research Group, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • McGinn R; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Nguyen LH; Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
  • Patel A; Clinical Epidemiology Program, Blueprint Translational Research Group, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Richebé P; Discipline of Anesthesia, Memorial University, St. John's, Newfoundland and Labrador, Canada.
  • Saha TK; Department of Anesthesiology, Université de Montréal, Montréal, Québec, Canada.
  • Steinberg BE; Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada.
  • Sampson SD; Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada.
  • Stewart DJ; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Syed S; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Vella K; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Wesch NL; Department of Anesthesiology, Université de Montréal, Montréal, Québec, Canada.
  • Lalu MM; Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada.
PLoS One ; 14(5): e0215221, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31120888
ABSTRACT
Poor reporting quality may contribute to irreproducibility of results and failed 'bench-to-bedside' translation. Consequently, guidelines have been developed to improve the complete and transparent reporting of in vivo preclinical studies. To examine the impact of such guidelines on core methodological and analytical reporting items in the preclinical anesthesiology literature, we sampled a cohort of studies. Preclinical in vivo studies published in Anesthesiology, Anesthesia & Analgesia, Anaesthesia, and the British Journal of Anaesthesia (2008-2009, 2014-2016) were identified. Data was extracted independently and in duplicate. Reporting completeness was assessed using the National Institutes of Health Principles and Guidelines for Reporting Preclinical Research. Risk ratios were used for comparative analyses. Of 7615 screened articles, 604 met our inclusion criteria and included experiments reporting on 52 490 animals. The most common topic of investigation was pain and analgesia (30%), rodents were most frequently used (77%), and studies were most commonly conducted in the United States (36%). Use of preclinical reporting guidelines was listed in 10% of applicable articles. A minority of studies fully reported on replicates (0.3%), randomization (10%), blinding (12%), sample-size estimation (3%), and inclusion/exclusion criteria (5%). Statistics were well reported (81%). Comparative analysis demonstrated few differences in reporting rigor between journals, including those that endorsed reporting guidelines. Principal items of study design were infrequently reported, with few differences between journals. Methods to improve implementation and adherence to community-based reporting guidelines may be necessary to increase transparent and consistent reporting in the preclinical anesthesiology literature.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Avaliação Pré-Clínica de Medicamentos / Relatório de Pesquisa Tipo de estudo: Guia de prática clínica Limite: Animais Idioma: Inglês Revista: PLoS One Assunto da revista: Ciência / Medicina Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Canadá

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Avaliação Pré-Clínica de Medicamentos / Relatório de Pesquisa Tipo de estudo: Guia de prática clínica Limite: Animais Idioma: Inglês Revista: PLoS One Assunto da revista: Ciência / Medicina Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Canadá
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