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Acute promyelocytic leukemia and variant fusion proteins: PLZF-RARα fusion protein at a glance.
Hussain, Liaqat; Maimaitiyiming, Yasen; Islam, Khairul; Naranmandura, Hua.
Afiliação
  • Hussain L; Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China.
  • Maimaitiyiming Y; Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China.
  • Islam K; Department of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou, China.
  • Naranmandura H; Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China; Department of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou, China. Electronic address: narenman@zju.edu.cn.
Semin Oncol ; 46(2): 133-144, 2019 04.
Article em En | MEDLINE | ID: mdl-31126665
ABSTRACT
Classical acute promyelocytic leukemia (APL) cases are associated with the promyelocytic leukemia-retinoic acid receptor α (PML-RARα) chimeric fusion protein. Almost all the variant chimeric proteins share the same RARα component. Currently, more than 11 fusion partners of RARα have been identified, of which PML accounts for 95%, promyelocytic leukemia zinc finger (PLZF) take up2%, and the remaining are other variants. Although all-trans retinoic acid and arsenic trioxide have shown remarkable induction of molecular remission in classical APL, they have no appreciable effects on APL associated with other variant gene fusions (eg, PLZF-RARα and STAT5b-RARα). Here, we summarize all variant translocations, their key features, their leukemogenic potential as well as recent advances in studies of PLZF-RARα-associated APL. Basic pathogenic differences between classical APL and PLZF-RARα-associated APL are further discussed. We also highlight the critical leukemogenic events that are the backbone of these variant translocations so as to gain new insights into refractory APL.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Promielocítica Aguda / Proteínas de Fusão Oncogênica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Semin Oncol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Promielocítica Aguda / Proteínas de Fusão Oncogênica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Semin Oncol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA