HLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review.
Rheumatol Int
; 39(9): 1643-1650, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31134290
ABSTRACT
Rickettsia rickettsii, a tick borne disease, is the pathogen responsible for inducing Rocky Mountain Spotted Fever (RMSF), an illness that can progress to fulminant multiorgan failure and death. We present a case where R. rickettsii, acquired on a camping trip, precipitated a flare of peripheral arthritis and episcleritis in an HLA-B27 positive patient. Although Yersinia, Salmonella, Mycobacteria, Chlamydia, Shigella, Campylobacter, and Brucella have been previously associated with HLA-B27 spondyloarthritis, this unusual case demonstrates that obligate intracellular rickettsial organisms, and specifically, R. rickettsii, can also induce flares of HLA-B27 spondyloarthritis. Rickettsial infections in general can rapidly become fatal in both healthy and immunosuppressed patients, and thus, prompt diagnosis and therapy are required.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rickettsia rickettsii
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Antígeno HLA-B27
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Hospedeiro Imunocomprometido
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Espondilartrite
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Certolizumab Pegol
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Rickettsiose do Grupo da Febre Maculosa
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Inibidores do Fator de Necrose Tumoral
Tipo de estudo:
Diagnostic_studies
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Rheumatol Int
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos