Correlation between SFRP1 expression and clinicopathological parameters in patients with triple-negative breast cancer.
Future Oncol
; 15(16): 1921-1938, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-31140870
ABSTRACT
Aim:
Breast cancer is a heterogeneous disease with distinct molecular and clinical behavior demanding reliable biomarkers, especially in triple-negative breast cancer (TNBC). This study seeks to improve the understanding of SFRP1 as a potential biomarker in breast cancer focusing on TNBC. Materials &methods:
SFRP1 expression was investigated via immunohistochemistry with two anti-SFRP1-antibodies on tissue-microarrays of 376 invasive breast cancers.Results:
Statistical analysis revealed a highly significant association between TNBC (n = 36) and SFRP1 expression (p < 0.001). SFRP1 expression was significantly associated with younger age, higher tumor stage, size and grade.Conclusion:
SFRP1 expression is strongly correlated with TNBC on protein level. Associations with age and tumor grade support the role of SFRP1 as a biomarker for chemotherapy response in TNBC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Expressão Gênica
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Neoplasias de Mama Triplo Negativas
/
Proteínas de Membrana
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Alemanha