Investigation of the mechanism of incompatible herb pair gansui-gancao-induced hepatotoxicity and nephrotoxicity and the attenuated effect of gansuibanxia decoction by UHPLC-FT-ICR-MS-based plasma metabonomic analysis.

Cui, Yue; Wang, Roujia; Zhang, Ye; Liu, Ting; Han, Fei; Li, Ruiyun; Zhang, Nan; Zhao, Yunli; Yu, Zhiguo

Cui, Yue; Wang, Roujia; Zhang, Ye; Liu, Ting; Han, Fei; Li, Ruiyun; Zhang, Nan; Zhao, Yunli; Yu, Zhiguo.

Afiliação

Cui Y; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Wang R; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Zhang Y; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Liu T; The Precise Medicine Center, Key Laboratory of Environmental Pollution and Microecology, Liaoning Province, College of Basic Medical Sciences, Shenyang Medical College, No. 146, North Huanghe Street, Huanggu District, Shenyang 110034, China.
Han F; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Li R; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Zhang N; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Zhao Y; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: yunli76@163.com.
Yu Z; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: zhiguo-yu@163.com.

J Pharm Biomed Anal ; 173: 176-182, 2019 Sep 05.

Article em En | MEDLINE | ID: mdl-31146173

Assuntos

Injúria Renal Aguda/induzido quimicamente; Doença Hepática Induzida por Substâncias e Drogas/etiologia; Medicamentos de Ervas Chinesas/efeitos adversos; Metabolômica/métodos; Injúria Renal Aguda/sangue; Animais; Asteraceae/química; Biomarcadores/sangue; Biomarcadores/metabolismo; Doença Hepática Induzida por Substâncias e Drogas/sangue; Cromatografia Líquida de Alta Pressão/métodos; Modelos Animais de Doenças; Incompatibilidade de Medicamentos; Medicamentos de Ervas Chinesas/metabolismo; Medicamentos de Ervas Chinesas/farmacocinética; Humanos; Masculino; Ratos; Ratos Sprague-Dawley

Palavras-chave

Eighteen; Gancao; Gansui; Gansuibanxia decoction; Incompatible; Metabonomic; UHPLC-FT-ICR-MS

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Metabolômica / Doença Hepática Induzida por Substâncias e Drogas / Injúria Renal Aguda Limite: Animals / Humans / Male Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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