Study on the absorption of corosolic acid in the gastrointestinal tract and its metabolites in rats.

Zhang, Biying; Lu, Yawen; Li, Ping; Wen, Xiaodong; Yang, Jie

Zhang, Biying; Lu, Yawen; Li, Ping; Wen, Xiaodong; Yang, Jie.

Afiliação

Zhang B; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China. Electronic address: 1631020089@stu.cpu.edu.cn.
Lu Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China. Electronic address: 1731020066@stu.cpu.edu.cn.
Li P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Wen X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China. Electronic address: xiaodongwen@cpu.edu.cn.
Yang J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China. Electronic address: 1020092098@cpu.edu.cn.

Toxicol Appl Pharmacol ; 378: 114600, 2019 09 01.

Article em En | MEDLINE | ID: mdl-31150656

Assuntos

Trato Gastrointestinal/metabolismo; Absorção Intestinal/fisiologia; Triterpenos/metabolismo; Animais; Bile/metabolismo; Linhagem Celular Tumoral; Citocromo P-450 CYP1A2/metabolismo; Citocromo P-450 CYP3A/metabolismo; Células HT29; Células Hep G2; Humanos; Masculino; Microssomos Hepáticos/metabolismo; Permeabilidade; Ratos; Ratos Sprague-Dawley

Palavras-chave

Corosolic acid; in situ gastric absorption; in situ single-pass perfusion; metabolite identification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Trato Gastrointestinal / Absorção Intestinal Limite: Animals / Humans / Male Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos

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