Novel CB1-ligands maintain homeostasis of the endocannabinoid system in &#969;3- and &#969;6-long-chain-PUFA deficiency.

Hammels, Ina; Binczek, Erika; Schmidt-Soltau, Inga; Jenke, Britta; Thomas, Andreas; Vogel, Matthias; Thevis, Mario; Filipova, Dilyana; Papadopoulos, Symeon; Stoffel, Wilhelm

Novel CB1-ligands maintain homeostasis of the endocannabinoid system in ω3- and ω6-long-chain-PUFA deficiency.

Hammels, Ina; Binczek, Erika; Schmidt-Soltau, Inga; Jenke, Britta; Thomas, Andreas; Vogel, Matthias; Thevis, Mario; Filipova, Dilyana; Papadopoulos, Symeon; Stoffel, Wilhelm.

Afiliação

Hammels I; Center of Molecular Medicine (CMMC), Laboratory of Molecular Neurosciences, Institute of Biochemistry, University of Cologne, 50931 Cologne, Germany.
Binczek E; Cluster of Excellence, Cellular Stress Response in Aging Related Diseases (CECAD) University of Cologne, 50931 Cologne, Germany.
Schmidt-Soltau I; Center of Molecular Medicine (CMMC), Laboratory of Molecular Neurosciences, Institute of Biochemistry, University of Cologne, 50931 Cologne, Germany.
Jenke B; Center of Molecular Medicine (CMMC), Laboratory of Molecular Neurosciences, Institute of Biochemistry, University of Cologne, 50931 Cologne, Germany.
Thomas A; Center of Molecular Medicine (CMMC), Laboratory of Molecular Neurosciences, Institute of Biochemistry, University of Cologne, 50931 Cologne, Germany.
Vogel M; Institute of Biochemistry Deutsche Sporthochschule (DSHS) Cologne, 50933 Cologne, Germany.
Thevis M; Institute of Biochemistry Deutsche Sporthochschule (DSHS) Cologne, 50933 Cologne, Germany.
Filipova D; Institute of Biochemistry Deutsche Sporthochschule (DSHS) Cologne, 50933 Cologne, Germany.
Papadopoulos S; Institute of Vegetative Physiology, Center of Physiology and Pathophysiology, University of Cologne, 50931 Cologne, Germany.
Stoffel W; Institute of Vegetative Physiology, Center of Physiology and Pathophysiology, University of Cologne, 50931 Cologne, Germany.

J Lipid Res ; 60(8): 1396-1409, 2019 08.

Article em En | MEDLINE | ID: mdl-31167809

Assuntos

Endocanabinoides/metabolismo; Ácidos Graxos Ômega-3/deficiência; Ácidos Graxos Ômega-6/deficiência; Receptor CB1 de Canabinoide/agonistas; Animais; Endocanabinoides/genética; Ácidos Graxos Dessaturases/deficiência; Ácidos Graxos Ômega-3/farmacologia; Ácidos Graxos Ômega-6/farmacologia; Células HEK293; Humanos; Camundongos; Camundongos Knockout; Receptor CB1 de Canabinoide/genética; Receptor CB1 de Canabinoide/metabolismo; Receptor CB2 de Canabinoide/agonistas; Receptor CB2 de Canabinoide/genética; Receptor CB2 de Canabinoide/metabolismo

Palavras-chave

20:35,11,14-endocannabinoids; arachidonic acid; cannabinoid receptor 1; diet effects; endocannabinoid system-orexin-circuitry; fatty acid desaturase 2-deficient mouse model; lipid metabolism; polyunsaturated fatty acid; surrogate cannabinoid receptor 1 ligands; ω3 fatty acids

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Graxos Ômega-3 / Ácidos Graxos Ômega-6 / Receptor CB1 de Canabinoide / Endocanabinoides Limite: Animals / Humans Idioma: En Revista: J Lipid Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google