The dominant models of KCNJ11 E23K and KCNMB1 E65K are associated with essential hypertension (EH) in Asian: Evidence from a meta-analysis.
Medicine (Baltimore)
; 98(23): e15828, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-31169684
ABSTRACT
BACKGROUND:
The K channel, subfamily J, member-11 (KCNJ11) E23K and ß1 subunit of large-conductance Ca-activated K channel (KCNMB1) E65K polymorphisms were shown to be associated with the risk of essential hypertension (EH). However, the results were inconclusive with relatively small sample size. Thus, we carried out a meta-analysis to investigate the genetic association between KCNJ11 E23K and KCNMB1 E65K polymorphisms and essential hypertension risk.METHODS:
Relative studies were collected using PubMed, Web of Science, the Cochrane Library databases, Chinese National Knowledge Infrastructure and Embase databases. Pooled odds ratios with 95% confidence intervals were used to assess the strength of associations.RESULTS:
The dominant models of KCNJ11 E23K (Pâ=â.006, OR [95%CI]â=â0.45 [0.25, 0.79]) and KCNMB1 E65K (Pâ=â.04, OR [95%CI]â=â0.91 [0.83, 1.00]) were significantly associated with essential hypertension risk. No significant association was detected between the allelic and recessive models of KCNJ11 E23K and KCNMB1 E65K and the susceptibility of EH. Subgroup analysis stratified by ethnicity showed that the dominant model of KCNMB1 E65K was associated with EH risk in Asian population (Pâ=â.003, OR [95%CI]â=â0.83 [0.74, 0.94]), but not in Caucasian (Pâ=â.74, OR [95%CI]â=â1.02 [0.89, 1.18]).CONCLUSIONS:
The dominant model of KCNJ11 E23K and KCNMB1 E65K might be susceptible factors for essential hypertension. To confirm this result, large-scale case-control studies with more subjects are necessary.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Potássio Corretores do Fluxo de Internalização
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Povo Asiático
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Subunidades beta do Canal de Potássio Ativado por Cálcio de Condutância Alta
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Hipertensão Essencial
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2019
Tipo de documento:
Article