The impact of IFNL3 genotype on interferon treatment outcome in patients chronically infected with hepatitis B virus: A meta-analysis.
Microb Pathog
; 134: 103598, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31201901
ABSTRACT
BACKGROUND:
Polymorphisms near the interferon lambda 3 (IFNL3, also known as IL28B) have been proposed to be associated with interferon (IFN)-induced hepatitis C virus (HCV) clearance, but the impact of IFNL3 variations on the result of IFN-based therapy in chronic hepatitis B (CHB) infection is still poor understood.METHODS:
The purpose of this study was to evaluate the relationship between the IFNL3 polymorphisms and the effectiveness of IFN therapy in patients infected with CHB by means of meta-analysis. PubMed and Embase were utilized to identify relevant studies. Odds ratio (OR) and 95% confidence interval (CI) were analysed together to assess the strength of the association. Subgroup analysis was mainly performed according to HBeAg.RESULTS:
Twelve studies of 1645 CHB patients met the inclusion criteria and were selected in our meta-analysis. One polymorphism, rs12979860, near to the IFNL3 gene had significant association with the response of CHB patients to IFN-based therapy (ORâ¯=â¯2.35, 95% CI 1.61-3.42 in allelic model). Another polymorphism, rs8099917, had a similar result (ORâ¯=â¯1.57, 95% CI 1.03-2.40 in dominant model; and ORâ¯=â¯1.88, 95% CI 1.21-2.90 in allelic model). When stratified by HBeAg, the antiviral outcome was markedly influenced by both two SNPs in HBeAg positive group (for rs12979860, ORâ¯=â¯1.90, 95% CI 1.31-2.76 and ORâ¯=â¯2.07, 95% CI 1.26-3.41 in dominant and allelic models respectively; for rs8099917, ORâ¯=â¯1.67, 95% CI 1.04-2.67 in dominant model and ORâ¯=â¯1.77, 95% CI 1.10-2.85 in allelic model).CONCLUSION:
We concluded that two polymorphisms (rs12979860 and rs8099917) of IFNL3 may play a crucial role in the IFN-based treatment of CHB, especially in HBeAg positive group.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Interferons
/
Hepatite B Crônica
/
Genótipo
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Microb Pathog
Assunto da revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM