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Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.
Gothe, Henrike Johanna; Bouwman, Britta Annika Maria; Gusmao, Eduardo Gade; Piccinno, Rossana; Petrosino, Giuseppe; Sayols, Sergi; Drechsel, Oliver; Minneker, Vera; Josipovic, Natasa; Mizi, Athanasia; Nielsen, Christian Friberg; Wagner, Eva-Maria; Takeda, Shunichi; Sasanuma, Hiroyuki; Hudson, Damien Francis; Kindler, Thomas; Baranello, Laura; Papantonis, Argyris; Crosetto, Nicola; Roukos, Vassilis.
Afiliação
  • Gothe HJ; Institute of Molecular Biology (IMB), Mainz 55128, Germany.
  • Bouwman BAM; Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Gusmao EG; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany; Department of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
  • Piccinno R; Institute of Molecular Biology (IMB), Mainz 55128, Germany.
  • Petrosino G; Institute of Molecular Biology (IMB), Mainz 55128, Germany.
  • Sayols S; Institute of Molecular Biology (IMB), Mainz 55128, Germany.
  • Drechsel O; Institute of Molecular Biology (IMB), Mainz 55128, Germany.
  • Minneker V; Institute of Molecular Biology (IMB), Mainz 55128, Germany.
  • Josipovic N; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany; Department of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
  • Mizi A; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany; Department of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
  • Nielsen CF; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
  • Wagner EM; Department of Hematology, Medical Oncology and Pneumology, University Medical Center of Mainz, Mainz, Germany.
  • Takeda S; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan.
  • Sasanuma H; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan.
  • Hudson DF; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
  • Kindler T; Department of Hematology, Medical Oncology and Pneumology, University Medical Center of Mainz, Mainz, Germany; University Cancer Center of Mainz, Mainz, Germany.
  • Baranello L; Department of Cell Molecular Biology, Karolinska Institute, Stockholm, Sweden.
  • Papantonis A; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany; Department of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
  • Crosetto N; Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Roukos V; Institute of Molecular Biology (IMB), Mainz 55128, Germany. Electronic address: v.roukos@imb-mainz.de.
Mol Cell ; 75(2): 267-283.e12, 2019 07 25.
Article em En | MEDLINE | ID: mdl-31202576
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Translocação Genética / Histona-Lisina N-Metiltransferase / DNA Topoisomerases Tipo II / Instabilidade Genômica / Proteína de Leucina Linfoide-Mieloide / Proteínas de Ligação a Poli-ADP-Ribose Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Translocação Genética / Histona-Lisina N-Metiltransferase / DNA Topoisomerases Tipo II / Instabilidade Genômica / Proteína de Leucina Linfoide-Mieloide / Proteínas de Ligação a Poli-ADP-Ribose Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos