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Functional MRI to Study Gait Impairment in Parkinson's Disease: a Systematic Review and Exploratory ALE Meta-Analysis.
Gilat, Moran; Dijkstra, Bauke W; D'Cruz, Nicholas; Nieuwboer, Alice; Lewis, Simon J G.
Afiliação
  • Gilat M; Department of Rehabilitation Sciences, KU Leuven, Tervuursevest 101, PO Box1501, Leuven, Belgium. moran.gilat@kuleuven.be.
  • Dijkstra BW; Department of Rehabilitation Sciences, KU Leuven, Tervuursevest 101, PO Box1501, Leuven, Belgium.
  • D'Cruz N; Department of Rehabilitation Sciences, KU Leuven, Tervuursevest 101, PO Box1501, Leuven, Belgium.
  • Nieuwboer A; Department of Rehabilitation Sciences, KU Leuven, Tervuursevest 101, PO Box1501, Leuven, Belgium.
  • Lewis SJG; Brain and Mind Centre, University of Sydney, Sydney, Australia.
Curr Neurol Neurosci Rep ; 19(8): 49, 2019 06 18.
Article em En | MEDLINE | ID: mdl-31214901
ABSTRACT
PURPOSE OF REVIEW Whilst gait impairment is a main cause for disability in Parkinson's disease (PD), its neural control remains poorly understood. We performed a systematic review and meta-analysis of neuroimaging studies of surrogate features of gait in PD.

FINDINGS:

Assessing the results from PET or SPECT scans after a period of actual walking as well as fMRI during mental imagery or virtual reality (VR) gait paradigms, we found a varying pattern of gait-related brain activity. Overall, a decrease in activation of the SMA during gait was found in PD compared to elderly controls. In addition, the meta-analysis showed that the most consistent gait-related activation was situated in the cerebellar locomotor region (CLR) in PD. Despite methodological heterogeneity, the combined neuroimaging studies of gait provide new insights into its neural control in PD, suggesting that CLR activation likely serves a compensatory role in locomotion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Transtornos Neurológicos da Marcha Tipo de estudo: Etiology_studies / Systematic_reviews Limite: Aged / Female / Humans / Male Idioma: En Revista: Curr Neurol Neurosci Rep Assunto da revista: NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Bélgica

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Transtornos Neurológicos da Marcha Tipo de estudo: Etiology_studies / Systematic_reviews Limite: Aged / Female / Humans / Male Idioma: En Revista: Curr Neurol Neurosci Rep Assunto da revista: NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Bélgica