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Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Minuesa, Gerard; Albanese, Steven K; Xie, Wei; Kazansky, Yaniv; Worroll, Daniel; Chow, Arthur; Schurer, Alexandra; Park, Sun-Mi; Rotsides, Christina Z; Taggart, James; Rizzi, Andrea; Naden, Levi N; Chou, Timothy; Gourkanti, Saroj; Cappel, Daniel; Passarelli, Maria C; Fairchild, Lauren; Adura, Carolina; Glickman, J Fraser; Schulman, Jessica; Famulare, Christopher; Patel, Minal; Eibl, Joseph K; Ross, Gregory M; Bhattacharya, Shibani; Tan, Derek S; Leslie, Christina S; Beuming, Thijs; Patel, Dinshaw J; Goldgur, Yehuda; Chodera, John D; Kharas, Michael G.
Afiliação
  • Minuesa G; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Albanese SK; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Xie W; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Kazansky Y; Structural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Worroll D; Weill Cornell Medical College, Tri-Institutional MD-PhD Program, Rockefeller University and Sloan Kettering Institute, New York, NY, 10065, USA.
  • Chow A; Department of Pharmacology, Weill Cornell Graduate School of Medical Sciences, New York, NY, 10065, USA.
  • Schurer A; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Park SM; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Rotsides CZ; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Taggart J; Chemical Biology Program, Sloan Kettering Institute and Tri-Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
  • Rizzi A; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Naden LN; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Chou T; Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medical College, New York, NY, 10065, USA.
  • Gourkanti S; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Cappel D; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Passarelli MC; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Fairchild L; Schrödinger GmbH, Q7, 23, 68161, Mannheim, Germany.
  • Adura C; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Glickman JF; Weill Cornell Medical College, Tri-Institutional MD-PhD Program, Rockefeller University and Sloan Kettering Institute, New York, NY, 10065, USA.
  • Schulman J; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Famulare C; Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medical College, New York, NY, 10065, USA.
  • Patel M; High-Throughput and Spectroscopy Resource Center, The Rockefeller University, New York, NY, 10065, USA.
  • Eibl JK; High-Throughput and Spectroscopy Resource Center, The Rockefeller University, New York, NY, 10065, USA.
  • Ross GM; Hematologic Oncology Tissue Bank, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Bhattacharya S; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Tan DS; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Leslie CS; Northern Ontario School of Medicine, Sudbury, ON, P3E 2C6, Canada.
  • Beuming T; Northern Ontario School of Medicine, Sudbury, ON, P3E 2C6, Canada.
  • Patel DJ; New York Structural Biology Center, NMR Group, New York, NY, 10027, USA.
  • Goldgur Y; Chemical Biology Program, Sloan Kettering Institute and Tri-Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
  • Chodera JD; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Kharas MG; Schrödinger, Inc., 120 West 45th Street, New York, NY, 10036, USA.
Nat Commun ; 10(1): 2691, 2019 06 19.
Article em En | MEDLINE | ID: mdl-31217428
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pteridinas / Leucemia Mieloide Aguda / Leucemia Experimental / Regulação Leucêmica da Expressão Gênica / Proteínas de Ligação a RNA Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pteridinas / Leucemia Mieloide Aguda / Leucemia Experimental / Regulação Leucêmica da Expressão Gênica / Proteínas de Ligação a RNA Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido