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Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.
Kazi, Aslamuzzaman; Xiang, Shengyan; Yang, Hua; Chen, Liwei; Kennedy, Perry; Ayaz, Muhammad; Fletcher, Steven; Cummings, Christopher; Lawrence, Harshani R; Beato, Francisca; Kang, Ya'an; Kim, Michael P; Delitto, Andrea; Underwood, Patrick W; Fleming, Jason B; Trevino, Jose G; Hamilton, Andrew D; Sebti, Said M.
Afiliação
  • Kazi A; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Xiang S; Department of Oncologic Sciences, University of South Florida, Tampa, Florida.
  • Yang H; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Chen L; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Kennedy P; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Ayaz M; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Fletcher S; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Cummings C; Chemical Biology Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Lawrence HR; University of Toronto, Ontario, Canada.
  • Beato F; Department of Chemistry, Yale University, New Haven, Connecticut.
  • Kang Y; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Kim MP; Department of Oncologic Sciences, University of South Florida, Tampa, Florida.
  • Delitto A; Chemical Biology Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Underwood PW; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Fleming JB; Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Trevino JG; Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Hamilton AD; Department of Surgery, University of Florida, Gainesville, Florida.
  • Sebti SM; Department of Surgery, University of Florida, Gainesville, Florida.
Clin Cancer Res ; 25(19): 5984-5996, 2019 10 01.
Article em En | MEDLINE | ID: mdl-31227505
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteínas Proto-Oncogênicas p21(ras) / Alquil e Aril Transferases / Inibidores Enzimáticos / Farnesiltranstransferase / Mutação Limite: Animals / Humans / Male Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteínas Proto-Oncogênicas p21(ras) / Alquil e Aril Transferases / Inibidores Enzimáticos / Farnesiltranstransferase / Mutação Limite: Animals / Humans / Male Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos