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Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3.
Kim, Dongwon; Chen, Ruosi; Sheu, Mary; Kim, Noori; Kim, Sooah; Islam, Nasif; Wier, Eric M; Wang, Gaofeng; Li, Ang; Park, Angela; Son, Wooyang; Evans, Benjamin; Yu, Victoria; Prizmic, Vicky P; Oh, Eugene; Wang, Zixiao; Yu, Jianshi; Huang, Weiliang; Archer, Nathan K; Hu, Zhiqi; Clemetson, Nashay; Nelson, Amanda M; Chien, Anna; Okoye, Ginette A; Miller, Lloyd S; Ghiaur, Gabriel; Kang, Sewon; Jones, Jace W; Kane, Maureen A; Garza, Luis A.
Afiliação
  • Kim D; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. dkim159@jhmi.edu.
  • Chen R; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Sheu M; Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
  • Kim N; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Kim S; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Islam N; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Wier EM; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Wang G; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Li A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Park A; Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
  • Son W; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Evans B; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Yu V; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Prizmic VP; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Oh E; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Wang Z; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Yu J; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Huang W; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Archer NK; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, 21201, USA.
  • Hu Z; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, 21201, USA.
  • Clemetson N; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Nelson AM; Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
  • Chien A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Okoye GA; Department of Dermatology, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA.
  • Miller LS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Ghiaur G; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Kang S; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Jones JW; Sidney Kimmel Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Kane MA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Garza LA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, 21201, USA.
Nat Commun ; 10(1): 2811, 2019 06 26.
Article em En | MEDLINE | ID: mdl-31243280
ABSTRACT
How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Tretinoína / RNA de Cadeia Dupla / Folículo Piloso / Receptor 3 Toll-Like Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Tretinoína / RNA de Cadeia Dupla / Folículo Piloso / Receptor 3 Toll-Like Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos