Elevated cyclic-AMP represses expression of exchange protein activated by cAMP (EPAC1) by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation.

Ebrahimighaei, Reza; McNeill, Madeleine C; Smith, Sarah A; Wray, Jason P; Ford, Kerrie L; Newby, Andrew C; Bond, Mark

Ebrahimighaei, Reza; McNeill, Madeleine C; Smith, Sarah A; Wray, Jason P; Ford, Kerrie L; Newby, Andrew C; Bond, Mark.

Afiliação

Ebrahimighaei R; School of Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
McNeill MC; School of Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
Smith SA; School of Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
Wray JP; School of Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
Ford KL; School of Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
Newby AC; School of Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
Bond M; School of Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK. Electronic address: mark.bond@bris.ac.uk.

Biochim Biophys Acta Mol Cell Res ; 1866(10): 1634-1649, 2019 10.

Article em En | MEDLINE | ID: mdl-31255721

Assuntos

AMP Cíclico/metabolismo; Fatores de Troca do Nucleotídeo Guanina/metabolismo; Processamento de Proteína Pós-Traducional; Citoesqueleto de Actina/metabolismo; Actinas/metabolismo; Amidas; Animais; Compostos Bicíclicos Heterocíclicos com Pontes/metabolismo; Técnicas de Cultura de Células; Linhagem Celular; Citocalasina D/metabolismo; Fibroblastos/metabolismo; Fatores de Troca do Nucleotídeo Guanina/genética; Histonas/metabolismo; Humanos; Masculino; Piridinas; RNA Mensageiro/metabolismo; Ratos; Ratos Sprague-Dawley; Tiazolidinas/metabolismo

Palavras-chave

ACTIN; EPAC; HDAC; TEAD; YAP; cAMP

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / AMP Cíclico / Fatores de Troca do Nucleotídeo Guanina Limite: Animals / Humans / Male Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Holanda

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