Design, synthesis and biological evaluation of 2-hydrazinyladenosine derivatives as A<sub>2A</sub> adenosine receptor ligands.

Zhang, Min; Fan, Shiyong; Zhou, Xinbo; Xie, Fei; Li, Song; Zhong, Wu

Design, synthesis and biological evaluation of 2-hydrazinyladenosine derivatives as A_2A adenosine receptor ligands.

Zhang, Min; Fan, Shiyong; Zhou, Xinbo; Xie, Fei; Li, Song; Zhong, Wu.

Afiliação

Zhang M; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China; General Hospital of Tibet Military Command, Lhasa, Tibet, 850007, PR China.
Fan S; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China.
Zhou X; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China.
Xie F; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China.
Li S; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China. Electronic address: lis.lisong@gmail.com.
Zhong W; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China. Electronic address: zhongwu@bmi.ac.cn.

Eur J Med Chem ; 179: 310-324, 2019 Oct 01.

Article em En | MEDLINE | ID: mdl-31255928

Assuntos

Adenosina/farmacologia; Desenho de Fármacos; Hidrazinas/farmacologia; Receptor A2A de Adenosina/metabolismo; Adenosina/análogos & derivados; Adenosina/química; AMP Cíclico/análise; Relação Dose-Resposta a Droga; Células HEK293; Humanos; Hidrazinas/síntese química; Hidrazinas/química; Ligantes; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

A(2A) agonist; Fragment-based drug design; G protein-coupled receptors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Adenosina / Receptor A2A de Adenosina / Hidrazinas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de publicação: França

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