Protein Translation and Psychiatric Disorders.
Neuroscientist
; 26(1): 21-42, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31271100
ABSTRACT
Although historically research has focused on transcription as the central governor of protein expression, protein translation is now increasingly being recognized as a major factor for determining protein levels within cells. The central nervous system relies on efficient updating of the protein landscape. Thus, coordinated regulation of mRNA localization, initiation, or termination of translation is essential for proper brain function. In particular, dendritic protein synthesis plays a key role in synaptic plasticity underlying learning and memory as well as cognitive processes. Increasing evidence suggests that impaired mRNA translation is a common feature found in numerous psychiatric disorders. In this review, we describe how malfunction of translation contributes to development of psychiatric diseases, including schizophrenia, major depression, bipolar disorder, and addiction.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Biossíntese de Proteínas
/
Transtorno Bipolar
/
Plasticidade Neuronal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neuroscientist
Assunto da revista:
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos