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Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors.
Abdel-Mohsen, Heba T; Omar, Mohamed A; El Kerdawy, Ahmed M; Mahmoud, Abeer E E; Ali, Mamdouh M; El Diwani, Hoda I.
Afiliação
  • Abdel-Mohsen HT; Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Dokki, Cairo, Egypt. Electronic address: hebabdelmohsen@gmail.com.
  • Omar MA; Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Dokki, Cairo, Egypt.
  • El Kerdawy AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt; Molecular Modeling Unit, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt; Department of Pharmaceutical Chemistry, Faculty of Phar
  • Mahmoud AEE; Department of Biochemistry, Division of Genetic Engineering and Biotechnology, National Research Centre, Cairo, Egypt.
  • Ali MM; Department of Biochemistry, Division of Genetic Engineering and Biotechnology, National Research Centre, Cairo, Egypt.
  • El Diwani HI; Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Dokki, Cairo, Egypt.
Eur J Med Chem ; 179: 707-722, 2019 Oct 01.
Article em En | MEDLINE | ID: mdl-31284081
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de publicação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de publicação: França