Developing a predictive in vitro dissolution model based on gastrointestinal fluid characterisation in rats.

Christfort, Juliane Fjelrad; Strindberg, Sophie; Plum, Jakob; Hall-Andersen, Jonatan; Janfelt, Christian; Nielsen, Line Hagner; Müllertz, Anette

Christfort, Juliane Fjelrad; Strindberg, Sophie; Plum, Jakob; Hall-Andersen, Jonatan; Janfelt, Christian; Nielsen, Line Hagner; Müllertz, Anette.

Afiliação

Christfort JF; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark; Department of Health Technology, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Strindberg S; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Plum J; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark; LEO Pharma A/S, Industriparken 55, DK-2750 Ballerup, Denmark(1).
Hall-Andersen J; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Janfelt C; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Nielsen LH; Department of Health Technology, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Müllertz A; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark; Bioneer:FARMA, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark. Electronic address: anette.mullertz@sund.ku.dk.

Eur J Pharm Biopharm ; 142: 307-314, 2019 Sep.

Article em En | MEDLINE | ID: mdl-31288077

Assuntos

Líquidos Corporais/metabolismo; Líquidos Corporais/fisiologia; Mucosa Gástrica/metabolismo; Intestino Delgado/metabolismo; Intestino Delgado/fisiologia; Preparações Farmacêuticas/metabolismo; Estômago/fisiologia; Animais; Humanos; Concentração de Íons de Hidrogênio; Masculino; Camundongos; Concentração Osmolar; Ratos; Ratos Sprague-Dawley; Solubilidade

Palavras-chave

Biorelevant media; Gastrointestinal fluids; In vitro in vivo correlation; Rats

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estômago / Líquidos Corporais / Preparações Farmacêuticas / Mucosa Gástrica / Intestino Delgado Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: Eur J Pharm Biopharm Assunto da revista: FARMACIA / FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: Holanda

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