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Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness.
Sharma, Arpit; Oonthonpan, Lalita; Sheldon, Ryan D; Rauckhorst, Adam J; Zhu, Zhiyong; Tompkins, Sean C; Cho, Kevin; Grzesik, Wojciech J; Gray, Lawrence R; Scerbo, Diego A; Pewa, Alvin D; Cushing, Emily M; Dyle, Michael C; Cox, James E; Adams, Chris; Davies, Brandon S; Shields, Richard K; Norris, Andrew W; Patti, Gary; Zingman, Leonid V; Taylor, Eric B.
Afiliação
  • Sharma A; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Oonthonpan L; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Sheldon RD; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Rauckhorst AJ; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Zhu Z; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Tompkins SC; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Cho K; Department of Chemistry, School of Medicine, Washington University, St. Louis, United States.
  • Grzesik WJ; Fraternal Order of the Eagles Diabetes Research Center (FOEDRC), Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Gray LR; FOEDRC Metabolic Phenotyping Core Facility, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Scerbo DA; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Pewa AD; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Cushing EM; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Dyle MC; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Cox JE; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Adams C; Department of Biochemistry, School of Medicine, University of Utah, Salt Lake City, United States.
  • Davies BS; Metabolomics Core Research Facility, School of Medicine, University of Utah, Salt Lake City, United States.
  • Shields RK; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Norris AW; Fraternal Order of the Eagles Diabetes Research Center (FOEDRC), Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Patti G; Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Zingman LV; Pappajohn Biomedical Institute, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Taylor EB; Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, United States.
Elife ; 82019 07 18.
Article em En | MEDLINE | ID: mdl-31305240
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Magreza / Músculo Esquelético / Ácido Pirúvico / Células Musculares / Redes e Vias Metabólicas / Glucose / Mitocôndrias Musculares Limite: Animals Idioma: En Revista: Elife Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Magreza / Músculo Esquelético / Ácido Pirúvico / Células Musculares / Redes e Vias Metabólicas / Glucose / Mitocôndrias Musculares Limite: Animals Idioma: En Revista: Elife Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido