Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology.

Wu, Wenchao; Wu, Jiangqing; Fu, Qiafan; Jin, Chenhao; Guo, Fangyuan; Yan, Qinying; Yang, Qingliang; Wu, Danjun; Yang, Yan; Yang, Gensheng

Wu, Wenchao; Wu, Jiangqing; Fu, Qiafan; Jin, Chenhao; Guo, Fangyuan; Yan, Qinying; Yang, Qingliang; Wu, Danjun; Yang, Yan; Yang, Gensheng.

Afiliação

Wu W; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Wu J; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Fu Q; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Jin C; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Guo F; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Yan Q; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Yang Q; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Wu D; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Yang Y; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Yang G; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.

Int J Nanomedicine ; 14: 4683-4695, 2019.

Article em En | MEDLINE | ID: mdl-31308653

Assuntos

Curcumina/farmacologia; Microfluídica/métodos; Nanopartículas/química; Polietilenoglicóis/química; Polímeros/química; Ácidos Tricarboxílicos/química; Células A549; Animais; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Curcumina/química; Curcumina/farmacocinética; Liberação Controlada de Fármacos; Endocitose/efeitos dos fármacos; Humanos; Camundongos; Peso Molecular; Nanopartículas/ultraestrutura; Tamanho da Partícula; Copolímero de Ácido Poliláctico e Ácido Poliglicólico/química; Ratos Sprague-Dawley; Distribuição Tecidual/efeitos dos fármacos

Palavras-chave

A549 cells; amiphiphilic three-arm copolymer; biodegradable nanoparticles; biodistribution; pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Polímeros / Ácidos Tricarboxílicos / Curcumina / Microfluídica / Nanopartículas Limite: Animals / Humans Idioma: En Revista: Int J Nanomedicine Ano de publicação: 2019 Tipo de documento: Article País de publicação: Nova Zelândia

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