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The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators.
Beider, Katia; Bitner, Hanna; Voevoda-Dimenshtein, Valeria; Rosenberg, Evgenia; Sirovsky, Yaarit; Magen, Hila; Canaani, Jonathan; Ostrovsky, Olga; Shilo, Noya; Shimoni, Avichai; Abraham, Michal; Weiss, Lola; Milyavsky, Michael; Peled, Amnon; Nagler, Arnon.
Afiliação
  • Beider K; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Bitner H; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Voevoda-Dimenshtein V; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Rosenberg E; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Sirovsky Y; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Magen H; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Canaani J; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Ostrovsky O; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Shilo N; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Shimoni A; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel.
  • Abraham M; Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, Jerusalem, Israel.
  • Weiss L; Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, Jerusalem, Israel.
  • Milyavsky M; Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Peled A; Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, Jerusalem, Israel.
  • Nagler A; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Tel Aviv University, Israel. Electronic address: Arnon.Nagler@sheba.health.gov.il.
Biochem Pharmacol ; 168: 412-428, 2019 10.
Article em En | MEDLINE | ID: mdl-31325448
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores CXCR4 / Proteínas rho de Ligação ao GTP / Inibidores de Histona Desacetilases / Everolimo / Panobinostat / Mitose / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Israel País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores CXCR4 / Proteínas rho de Ligação ao GTP / Inibidores de Histona Desacetilases / Everolimo / Panobinostat / Mitose / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Israel País de publicação: Reino Unido