Investigating the safety and efficacy of nabilone for the treatment of agitation in patients with moderate-to-severe Alzheimer's disease: Study protocol for a cross-over randomized controlled trial.

Ruthirakuhan, Myuri T; Herrmann, Nathan; Gallagher, Damien; Andreazza, Ana C; Kiss, Alexander; Verhoeff, Nicolaas Paul L G; Black, Sandra E; Lanctôt, Krista L

Ruthirakuhan, Myuri T; Herrmann, Nathan; Gallagher, Damien; Andreazza, Ana C; Kiss, Alexander; Verhoeff, Nicolaas Paul L G; Black, Sandra E; Lanctôt, Krista L.

Afiliação

Ruthirakuhan MT; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
Herrmann N; Department of Pharmacology, University of Toronto, 1 King's College Circle, M5S 3K1, Toronto, ON, Canada.
Gallagher D; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
Andreazza AC; Department of Psychiatry, University of Toronto, 1 King's College Circle, M5S 3K1, Toronto, ON, Canada.
Kiss A; Geriatric Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
Verhoeff NPLG; Geriatric Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
Black SE; Department of Pharmacology, University of Toronto, 1 King's College Circle, M5S 3K1, Toronto, ON, Canada.
Lanctôt KL; Department of Research Design and Biostatistics, Sunnybrook Research Institute, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.

Contemp Clin Trials Commun ; 15: 100385, 2019 Sep.

Article em En | MEDLINE | ID: mdl-31338476

Palavras-chave

AD, Alzheimer's disease; Agitation; Alzheimer's disease; CB, cannabinoids; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; CGIC, Clinician's Global Impression of Change; CMAI, Cohen Mansfield Agitation Inventory; Cannabinoid; Clinical trial; EC50, half maximal effective concentration; FDA, Food and Drug Administration; IPA, International Psychogeriatric Association; LTC, long-term care; MAR, Medication Administration Record; MNA-SF, Mini-Nutritional Assessment-Short form; NPI-NH, Neuropsychiatric Inventory-Nursing home version; NPS, neuropsychiatric symptoms; Neuropsychiatric symptoms; PAINAD, Pain Assessment in Advanced AD; RCT, randomized controlled trial; SIB, Severe Impairment Battery; THC, tetrahydrocannabinol; sMMSE, standardized Mini-Mental Status Examination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline Aspecto: Patient_preference Idioma: En Revista: Contemp Clin Trials Commun Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá

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