Genetic diversity of HLA system in two populations from Chiapas, Mexico: Tuxtla Gutiérrez and rural Chiapas.
Hum Immunol
; 81(9): 563-565, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-31345692
ABSTRACT
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 173 Mexicans from the state of Chiapas living in the city of Tuxtla Gutiérrez (Nâ¯=â¯52) and rural communities (Nâ¯=â¯121), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Chiapas include 12 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Chiapas are Native American (71.61⯱â¯0.58% by ML; 53.16% of Native American haplotypes) and European (26.39⯱â¯5.05% by ML; 25.86% of European haplotypes), and a less prominent African genetic component (2.00⯱â¯5.20% by ML; 9.77% of African haplotypes).
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
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Etnicidade
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Genética Populacional
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Antígenos HLA
Limite:
Humans
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Hum Immunol
Ano de publicação:
2020
Tipo de documento:
Article