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A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Pérez-Areales, F Javier; Turcu, Andreea L; Barniol-Xicota, Marta; Pont, Caterina; Pivetta, Deborah; Espargaró, Alba; Bartolini, Manuela; De Simone, Angela; Andrisano, Vincenza; Pérez, Belén; Sabate, Raimon; Sureda, Francesc X; Vázquez, Santiago; Muñoz-Torrero, Diego.
Afiliação
  • Pérez-Areales FJ; Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain.
  • Turcu AL; Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain.
  • Barniol-Xicota M; Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain.
  • Pont C; Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain.
  • Pivetta D; Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain.
  • Espargaró A; Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain.
  • Bartolini M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, I-40126, Bologna, Italy.
  • De Simone A; Department for Life Quality Studies, Alma Mater Studiorum University of Bologna, Corso D'Augusto 237, I-47921, Rimini, Italy.
  • Andrisano V; Department for Life Quality Studies, Alma Mater Studiorum University of Bologna, Corso D'Augusto 237, I-47921, Rimini, Italy.
  • Pérez B; Department of Pharmacology, Therapeutics, and Toxicology, Autonomous University of Barcelona, E-08193, Bellaterra, Spain.
  • Sabate R; Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain.
  • Sureda FX; Pharmacology Unit, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, C/St. Llorenç 21, E-43201, Reus, Spain.
  • Vázquez S; Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain. Electronic address: svazquez@ub.edu.
  • Muñoz-Torrero D; Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain. Electronic address: dmunoztorrero@ub.edu.
Eur J Med Chem ; 180: 613-626, 2019 Oct 15.
Article em En | MEDLINE | ID: mdl-31351393
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tacrina / Adamantano / Inibidores da Colinesterase / Fármacos Neuroprotetores / Doença de Alzheimer Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha País de publicação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tacrina / Adamantano / Inibidores da Colinesterase / Fármacos Neuroprotetores / Doença de Alzheimer Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha País de publicação: França