Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors.

Gan, Jingjing; Liu, Chunyan; Li, Huanling; Wang, Shaocong; Wang, Zhenzhen; Kang, Zhiqian; Huang, Zhen; Zhang, Junfeng; Wang, Chunming; Lv, Dalun; Dong, Lei

Gan, Jingjing; Liu, Chunyan; Li, Huanling; Wang, Shaocong; Wang, Zhenzhen; Kang, Zhiqian; Huang, Zhen; Zhang, Junfeng; Wang, Chunming; Lv, Dalun; Dong, Lei.

Afiliação

Gan J; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China.
Liu C; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China.
Li H; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China.
Wang S; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China.
Wang Z; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China.
Kang Z; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China.
Huang Z; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China.
Zhang J; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China.
Wang C; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China.
Lv D; Department of Burn and Plastic Surgery, First Affiliated Hospital of Wannan Medical College, Jinghu District, Wuhu City, Anhui Province, 241000, China. Electronic address: ldl0776@126.com.
Dong L; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China. Electronic address: leidong@nju.edu.cn.

Biomaterials ; 219: 119340, 2019 10.

Article em En | MEDLINE | ID: mdl-31357007

Assuntos

Diabetes Mellitus Experimental/patologia; Lectinas Tipo C/metabolismo; Macrófagos/patologia; Lectinas de Ligação a Manose/metabolismo; Receptores de Superfície Celular/metabolismo; Cicatrização; Animais; Diferenciação Celular; Linhagem Celular; Movimento Celular; Polaridade Celular; Proliferação de Células; Colágeno/metabolismo; Fibroblastos/patologia; Inflamação/patologia; Masculino; Mananas/química; Receptor de Manose; Camundongos Endogâmicos C57BL; Nanopartículas/química; Neovascularização Fisiológica; Comunicação Parácrina; Fenótipo; Regeneração; Dióxido de Silício/química; Pele/patologia

Palavras-chave

Macrophage; Mannose receptor; Receptor clustering; Wound healing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cicatrização / Receptores de Superfície Celular / Lectinas Tipo C / Lectinas de Ligação a Manose / Diabetes Mellitus Experimental / Macrófagos Limite: Animals Idioma: En Revista: Biomaterials Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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