Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors.

Wang, Lijiao; Li, Chao; Chen, Wei; Song, Chen; Zhang, Xing; Yang, Fan; Wang, Chen; Zhang, Yuanyuan; Qian, Shan; Wang, Zhouyu; Yang, Lingling

Wang, Lijiao; Li, Chao; Chen, Wei; Song, Chen; Zhang, Xing; Yang, Fan; Wang, Chen; Zhang, Yuanyuan; Qian, Shan; Wang, Zhouyu; Yang, Lingling.

Afiliação

Wang L; College of Food and Bioengineering, Xihua University, Sichuan 610039, China.
Li C; College of Food and Bioengineering, Xihua University, Sichuan 610039, China.
Chen W; College of Food and Bioengineering, Xihua University, Sichuan 610039, China.
Song C; College of Food and Bioengineering, Xihua University, Sichuan 610039, China.
Zhang X; College of Science, Xihua University, Sichuan 610039, China.
Yang F; College of Food and Bioengineering, Xihua University, Sichuan 610039, China.
Wang C; College of Food and Bioengineering, Xihua University, Sichuan 610039, China.
Zhang Y; College of Science, Xihua University, Sichuan 610039, China.
Qian S; College of Food and Bioengineering, Xihua University, Sichuan 610039, China.
Wang Z; College of Science, Xihua University, Sichuan 610039, China. zhouyuwang77@gmail.com.
Yang L; College of Food and Bioengineering, Xihua University, Sichuan 610039, China. yangll0808@sina.com.

Molecules ; 24(15)2019 Jul 26.

Article em En | MEDLINE | ID: mdl-31357491

Assuntos

Descoberta de Drogas; Inibidores de Histona Desacetilases/química; Metilaminas/química; Sirtuína 2/química; Inibidores de Histona Desacetilases/farmacologia; Humanos; Metilaminas/farmacologia; Modelos Moleculares; Conformação Molecular; Estrutura Molecular; Sirtuína 2/antagonistas & inibidores; Relação Estrutura-Atividade

Palavras-chave

SAR studies; SIRT2; histone deacetylases; molecular docking; sirtuins

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Sirtuína 2 / Inibidores de Histona Desacetilases / Metilaminas Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Suíça

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