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A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors.
Aloia, Andrea; Müllhaupt, Daniela; Chabbert, Christophe D; Eberhart, Tanja; Flückiger-Mangual, Stefanie; Vukolic, Ana; Eichhoff, Ossia; Irmisch, Anja; Alexander, Leila T; Scibona, Ernesto; Frederick, Dennie T; Miao, Benchun; Tian, Tian; Cheng, Chaoran; Kwong, Lawrence N; Wei, Zhi; Sullivan, Ryan J; Boland, Genevieve M; Herlyn, Meenhard; Flaherty, Keith T; Zamboni, Nicola; Dummer, Reinhard; Zhang, Gao; Levesque, Mitchell P; Krek, Wilhelm; Kovacs, Werner J.
Afiliação
  • Aloia A; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland. werner.kovacs@biol.ethz.ch aloia.andrea@libero.it.
  • Müllhaupt D; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
  • Chabbert CD; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
  • Eberhart T; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
  • Flückiger-Mangual S; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
  • Vukolic A; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
  • Eichhoff O; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
  • Irmisch A; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
  • Alexander LT; Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
  • Scibona E; Institute of Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland.
  • Frederick DT; Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  • Miao B; Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  • Tian T; Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey.
  • Cheng C; Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey.
  • Kwong LN; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Wei Z; Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey.
  • Sullivan RJ; Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  • Boland GM; Department of Surgery, Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  • Herlyn M; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute, Philadelphia, Pennsylvania.
  • Flaherty KT; Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  • Zamboni N; Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
  • Dummer R; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
  • Zhang G; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute, Philadelphia, Pennsylvania.
  • Levesque MP; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
  • Krek W; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
  • Kovacs WJ; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland. werner.kovacs@biol.ethz.ch aloia.andrea@libero.it.
Clin Cancer Res ; 25(22): 6852-6867, 2019 11 15.
Article em En | MEDLINE | ID: mdl-31375515
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredução / Adaptação Biológica / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Ácidos Graxos / Melanoma / Mutação Limite: Animals / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredução / Adaptação Biológica / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Ácidos Graxos / Melanoma / Mutação Limite: Animals / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos