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A Reactive Antibody Platform for One-Step Production of Antibody-Drug Conjugates through a Diels-Alder Reaction with Maleimide.
St Amant, Andre H; Huang, Fengying; Lin, Jia; Lemen, Daniel; Chakiath, Chacko; Mao, Shenlan; Fazenbaker, Christine; Zhong, Haihong; Harper, Jay; Xu, Wenshu; Patel, Neki; Adams, Lauren; Vijayakrishnan, Balakumar; Howard, Philip W; Marelli, Marcello; Wu, Herren; Gao, Changshou; Read de Alaniz, Javier; Christie, R James.
Afiliação
  • St Amant AH; Department of Chemistry and Biochemistry , University of California , Santa Barbara , California 93106-9510 , United States.
  • Huang F; Antibody Discovery and Protein Engineering Department , AstraZeneca R&D , Gaithersburg , Maryland 20878 , United States.
  • Lin J; Antibody Discovery and Protein Engineering Department , AstraZeneca R&D , Gaithersburg , Maryland 20878 , United States.
  • Lemen D; Antibody Discovery and Protein Engineering Department , AstraZeneca R&D , Gaithersburg , Maryland 20878 , United States.
  • Chakiath C; Antibody Discovery and Protein Engineering Department , AstraZeneca R&D , Gaithersburg , Maryland 20878 , United States.
  • Mao S; AstraZeneca Oncology R&D , Gaithersburg , Maryland 20878 , United States.
  • Fazenbaker C; AstraZeneca Oncology R&D , Gaithersburg , Maryland 20878 , United States.
  • Zhong H; AstraZeneca Oncology R&D , Gaithersburg , Maryland 20878 , United States.
  • Harper J; AstraZeneca Oncology R&D , Gaithersburg , Maryland 20878 , United States.
  • Xu W; Spirogen , London E1 2AX , United Kingdom.
  • Patel N; Spirogen , London E1 2AX , United Kingdom.
  • Adams L; Spirogen , London E1 2AX , United Kingdom.
  • Vijayakrishnan B; Spirogen , London E1 2AX , United Kingdom.
  • Howard PW; Spirogen , London E1 2AX , United Kingdom.
  • Marelli M; AstraZeneca Oncology R&D , Gaithersburg , Maryland 20878 , United States.
  • Wu H; Antibody Discovery and Protein Engineering Department , AstraZeneca R&D , Gaithersburg , Maryland 20878 , United States.
  • Gao C; Antibody Discovery and Protein Engineering Department , AstraZeneca R&D , Gaithersburg , Maryland 20878 , United States.
  • Read de Alaniz J; Department of Chemistry and Biochemistry , University of California , Santa Barbara , California 93106-9510 , United States.
  • Christie RJ; Antibody Discovery and Protein Engineering Department , AstraZeneca R&D , Gaithersburg , Maryland 20878 , United States.
Bioconjug Chem ; 30(9): 2340-2348, 2019 09 18.
Article em En | MEDLINE | ID: mdl-31380623
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoconjugados / Maleimidas Limite: Animals / Humans Idioma: En Revista: Bioconjug Chem Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoconjugados / Maleimidas Limite: Animals / Humans Idioma: En Revista: Bioconjug Chem Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos