GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway.

Zhang, Ziqiang; Xue, Hongyuan; Dong, Yuanqiang; Zhang, Jun; Pan, Yida; Shi, Liubin; Xiong, Panpan; Zhu, Jie; Li, Wenshuai; Zheng, Wanwei; Liu, Jie; Du, Jianjun

Zhang, Ziqiang; Xue, Hongyuan; Dong, Yuanqiang; Zhang, Jun; Pan, Yida; Shi, Liubin; Xiong, Panpan; Zhu, Jie; Li, Wenshuai; Zheng, Wanwei; Liu, Jie; Du, Jianjun.

Afiliação

Zhang Z; Departments of General Surgery, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Xue H; Departments of General Surgery, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Dong Y; Departments of General Surgery, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Zhang J; Departments of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Pan Y; Departments of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Shi L; Departments of General Surgery, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Xiong P; Departments of Digestive Diseases, Dongfang Hospital, Tongji University, Shanghai, China.
Zhu J; Departments of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Li W; Departments of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Zheng W; Departments of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Liu J; Departments of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China. jieliu@fudan.edu.cn.
Du J; Departments of General Surgery, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China. dujjp@hotmail.com.

J Exp Clin Cancer Res ; 38(1): 338, 2019 Aug 05.

Article em En | MEDLINE | ID: mdl-31382983

Assuntos

Apoptose; Proteínas de Transporte/metabolismo; Proteínas de Choque Térmico HSC70/metabolismo; Estresse Oxidativo; Transdução de Sinais; Neoplasias Gástricas/metabolismo; Adulto; Idoso; Animais; Antineoplásicos/uso terapêutico; Proteínas de Transporte/genética; Caspases; Linhagem Celular Tumoral; Dioxolanos/farmacologia; Modelos Animais de Doenças; Feminino; Expressão Gênica; Técnicas de Silenciamento de Genes; Genes Reporter; Humanos; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; Masculino; Camundongos; Pessoa de Meia-Idade; NF-kappa B/metabolismo; Oxirredução; Ligação Proteica; Neoplasias Gástricas/diagnóstico; Neoplasias Gástricas/tratamento farmacológico; Neoplasias Gástricas/genética; Resultado do Tratamento; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Apoptosis; GKN2; Gastric cancer; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Transdução de Sinais / Proteínas de Transporte / Apoptose / Estresse Oxidativo / Proteínas de Choque Térmico HSC70 Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido

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