Basing on uPAR-binding fragment to design chimeric antigen receptors triggers antitumor efficacy against uPAR expressing ovarian cancer cells.

Wang, Liang; Yang, Rulin; Zhao, Liping; Zhang, Xiwen; Xu, Tianmin; Cui, Manhua

Wang, Liang; Yang, Rulin; Zhao, Liping; Zhang, Xiwen; Xu, Tianmin; Cui, Manhua.

Afiliação

Wang L; Department of Gynecology and Obstetrics, the Second Hospital of Jilin University, Changchun, 130041, Jilin, China. Electronic address: wangliang7012@mails.jlu.edu.cn.
Yang R; Department of Gynecology and Obstetrics, the Second Hospital of Jilin University, Changchun, 130041, Jilin, China. Electronic address: yangrulin1989@126.com.
Zhao L; Department of Gynecology and Obstetrics, the Second Hospital of Jilin University, Changchun, 130041, Jilin, China. Electronic address: zhaoliping0411@126.com.
Zhang X; Department of Gynecology and Obstetrics, the Second Hospital of Jilin University, Changchun, 130041, Jilin, China. Electronic address: 13044306827@163.com.
Xu T; Department of Gynecology and Obstetrics, the Second Hospital of Jilin University, Changchun, 130041, Jilin, China. Electronic address: xutianmin@126.com.
Cui M; Department of Gynecology and Obstetrics, the Second Hospital of Jilin University, Changchun, 130041, Jilin, China. Electronic address: cuimanhua@126.com.

Biomed Pharmacother ; 117: 109173, 2019 Sep.

Article em En | MEDLINE | ID: mdl-31387176

Assuntos

Proteínas de Membrana/metabolismo; Neoplasias Ovarianas/metabolismo; Receptores de Antígenos Quiméricos/metabolismo; Adulto; Idoso; Antineoplásicos/farmacologia; Linhagem Celular; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Feminino; Células HEK293; Humanos; Imunoterapia/métodos; Pessoa de Meia-Idade; Metástase Neoplásica/tratamento farmacológico; Neoplasias Ovarianas/tratamento farmacológico; Neoplasias Ovarianas/terapia; Regulação para Cima/efeitos dos fármacos; Adulto Jovem

Palavras-chave

Chimeric antigen receptor; Cytokines; Effector to target ratio; Granzyme B; Ovarian cancer; UPAR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Receptores de Antígenos Quiméricos / Proteínas de Membrana Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2019 Tipo de documento: Article País de publicação: França

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