Water-Dispersible Bismuth-Organic Materials with Computed Tomography Contrast Properties.

ABSTRACT

Two bismuth-organic network polymers were synthesized by means of a one-step polycondensation reaction between an aromatic dithiol/trithiol and triphenylbismuth. The materials were characterized by solid-state UV-vis spectroscopy, Raman spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, powder X-ray diffraction, elemental microanalysis, and thermogravimetric analysis. Uniform dispersion of the hydrophobic and water-insoluble bismuth-containing polymers in aqueous media was achieved by the addition of 2 kDa poly(ethylene glycol) methyl ether thiol. This enabled quantitative phantom imaging experiments on a clinical computed tomography (CT) scanner, which showed that the coordination polymers possessed strong CT contrast properties. The observed X-ray attenuation properties of each coordination polymer were correlated with its bismuth payload. The X-ray opacity, thermal and chemical stabilities, and aqueous dispersibility of this novel class of bismuth-organic materials make them potentially useful as biomedical CT contrast agents and radiopaque materials.